Americas New Urine Test Could Spot Lung Cancer Months Before Symptoms Appear

Scientists from the University of Cambridge and Early Cancer Institute have developed a groundbreaking urine test to detect early signs of lung cancer. The test identifies proteins from senescent cells in the lungs, offering a cheaper alternative to scans for early cancer detection. Successful tests in mice show promise for human use.

Scientists from the University of Cambridge and the Early Cancer Institute have developed a groundbreaking urine test that could detect early signs of lung cancer. The test, funded by Cancer Research UK, identifies proteins released by senescent or "zombie" cells in the lungs, which can reprogram the surrounding tissue and promote cancer cell growth. These senescent cells, while alive, do not divide, but they contribute to the development of cancer by altering the tissue environment.

The researchers created an injectable sensor that interacts with the proteins released by these cells, making it possible to detect a compound in urine. In successful tests on mice, the urine test could identify early cancer indicators before symptoms were apparent. The scientists aim to make the test more accessible and affordable compared to traditional scans.

The hope is that this test could enable early detection of lung cancer months or even years before symptoms appear. By monitoring changes in the urine color after the injection of a silver solution, the test can detect the presence of senescent cells in the lungs, offering a potential breakthrough in cancer diagnosis.