An EgyptAir flight from Paris to Cairo has disappeared from radar with 66 people on board, the airline says.
The Airbus A320 went missing over the eastern Mediterranean, soon after entering Egyptian airspace.
EgyptAir says it received a distress signal before the plane disappeared from radar.
There were 56 passengers - including three children - seven crew members and three security personnelon board Flight MS804, the airline said.
The airline said the passengers included: 30 Egyptians, 15 French citizens, one Briton, two Iraqis, as well as people from Canada, Belgium, Kuwait, Saudi Arabia, Algeria, Sudan, Chad and Portugal.
Flight MS804 left Paris' Charles de Gaulle airport at 23:09 local time on Wednesday (21:09 GMT) and was scheduled to arrive in the Egyptian capital soon after 03:00 local time on Thursday.
It was flying at 37,000ft (11,300m) over the eastern Mediterranean when contact was lost, at 02:45 Cairo time (00:45 GMT).
The Greek authorities joined Egyptian armed forces in the search operation.
Egyptian Prime Minister Sherif Ismail has arrived at the airport in Cairo, along with the families of those on board, state-run Nile News TV reports.
Aviation analyst Alex Macheras told the BBC that Airbus A320s were regularly used for short-haul budget flights and had "an amazing safety record".
In March, an EgyptAir plane was hijacked and diverted to Cyprus. The attacker later surrendered and all hostages were released.
Last October, a Russian passenger plane flying from Sharm el-Sheikh crashed over the Sinai peninsula killing all 224 people on board. Officials in Moscow and Egypt later said the aircraft was brought down by an explosive device.
Islamic State militants said they had bombed the plane.